1xu6

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{{STRUCTURE_1xu6| PDB=1xu6 | SCENE= }}
{{STRUCTURE_1xu6| PDB=1xu6 | SCENE= }}
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'''Structure of the C-terminal domain from Trypanosoma brucei Variant Surface Glycoprotein MITat1.2'''
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===Structure of the C-terminal domain from Trypanosoma brucei Variant Surface Glycoprotein MITat1.2===
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==Overview==
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The variant surface glycoprotein (VSG) of African trypanosomes has a structural role in protecting other cell surface proteins from effector molecules of the mammalian immune system and also undergoes antigenic variation necessary for a persistent infection in a host. Here we have reported the solution structure of a VSG type 2 C-terminal domain from MITat1.2, completing the first structure of both domains of a VSG. The isolated C-terminal domain is a monomer in solution and forms a novel fold, which commences with a short alpha-helix followed by a single turn of 3(10)-helix and connected by a short loop to a small anti-parallel beta-sheet and then a longer alpha-helix at the C terminus. This compact domain is flanked by two unstructured regions. The structured part of the domain contains 42 residues, and the core comprises 2 disulfide bonds and 2 hydrophobic residues. These cysteines and hydrophobic residues are conserved in other VSGs, and we have modeled the structures of two further VSG C-terminal domains using the structure of MITat1.2. The models suggest that the overall structure of the core is conserved in the different VSGs but that the C-terminal alpha-helix is of variable length and depends on the presence of charged residues. The results provided evidence for a conserved tertiary structure for all the type 2 VSG C-terminal domains, indicated that VSG dimers form through interactions between N-terminal domains, and showed that the selection pressure for sequence variation within a conserved tertiary structure acts on the whole of the VSG molecule.
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{{ABSTRACT_PUBMED_15557330}}
==About this Structure==
==About this Structure==
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1XU6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU6 OCA].
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1XU6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XU6 OCA].
==Reference==
==Reference==
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[[Category: Voorheis, H P.]]
[[Category: Voorheis, H P.]]
[[Category: Cysteine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:30:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:38:44 2008''

Revision as of 16:38, 27 July 2008

Image:1xu6.png

Template:STRUCTURE 1xu6

Structure of the C-terminal domain from Trypanosoma brucei Variant Surface Glycoprotein MITat1.2

Template:ABSTRACT PUBMED 15557330

About this Structure

1XU6 is a Single protein structure of sequence from Trypanosoma brucei brucei. Full experimental information is available from OCA.

Reference

Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2., Chattopadhyay A, Jones NG, Nietlispach D, Nielsen PR, Voorheis HP, Mott HR, Carrington M, J Biol Chem. 2005 Feb 25;280(8):7228-35. Epub 2004 Nov 22. PMID:15557330

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