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1xvm

From Proteopedia

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[[Image:1xvm.gif|left|200px]]
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[[Image:1xvm.png|left|200px]]
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{{STRUCTURE_1xvm| PDB=1xvm | SCENE= }}
{{STRUCTURE_1xvm| PDB=1xvm | SCENE= }}
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'''Trypsin from Fusarium oxysporum- room temperature to atomic resolution'''
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===Trypsin from Fusarium oxysporum- room temperature to atomic resolution===
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==Overview==
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The analysis of anisotropic atomic displacement parameters for the direct extraction of functionally relevant motion from X-ray crystal structures of Fusarium oxysporum trypsin is presented. Several atomic resolution structures complexed with inhibitors or substrates and determined at different pH values and temperatures were investigated. The analysis revealed a breathing-like molecular motion conserved across trypsin structures from two organisms and three different crystal forms. Directional motion was observed suggesting a change of the width of the substrate-binding cleft and a change in the length of the specificity pocket. The differences in direction of motion across the structures are dependent on the mode of substrate or inhibitor binding and the chemical environment around the active-site residues. Together with the occurrence of multiple-residue conformers, they reflect spatial rearrangement throughout the deacylation pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 16041079 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16041079}}
==About this Structure==
==About this Structure==
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[[Category: Mobility]]
[[Category: Mobility]]
[[Category: Room temperature]]
[[Category: Room temperature]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:33:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:51:44 2008''

Revision as of 16:51, 27 July 2008

Image:1xvm.png

Template:STRUCTURE 1xvm

Trypsin from Fusarium oxysporum- room temperature to atomic resolution

Template:ABSTRACT PUBMED 16041079

About this Structure

1XVM is a Single protein structure of sequence from Fusarium oxysporum. Full crystallographic information is available from OCA.

Reference

Extraction of functional motion in trypsin crystal structures., Schmidt A, Lamzin VS, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1132-9. Epub 2005, Jul 20. PMID:16041079

Page seeded by OCA on Sun Jul 27 19:51:44 2008

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