1xvr

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{{Seed}}
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{{STRUCTURE_1xvr| PDB=1xvr | SCENE= }}
{{STRUCTURE_1xvr| PDB=1xvr | SCENE= }}
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'''echinomycin (CGTACG)2 complex'''
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===echinomycin (CGTACG)2 complex===
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==Overview==
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The structure of the bis-intercalation complex of the depsipeptide antibiotic echinomycin with (CGTACG)2 has been redetermined at a higher resolution (1.4 A) and new high-resolution structures (1.1-1.5 A) are reported for the complexes of echinomycin with (GCGTACGC)2 (at both low and high ionic strengths) and (ACGTACGT)2. The structures show the expected Hoogsteen pairing for the base pairs flanking the intercalating chromophores on the outside and Watson-Crick pairing for both base pairs enclosed by the echinomycin. In the octamer complexes but not the hexamer complex, the echinomycin molecule, which would possess a molecular twofold axis were it not for the thioacetal bridge, shows twofold disorder. In all the structures the stacking of the base pairs and chromophores is extended by intermolecular stacking. The structures provide more precise details of the hydrogen bonding and other interactions between the bis-intercalating antibiotics and the duplex DNA than were previously available.
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(as it appears on PubMed at http://www.pubmed.gov), where 15805599 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15805599}}
==About this Structure==
==About this Structure==
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[[Category: Bisintercalator]]
[[Category: Bisintercalator]]
[[Category: Hoogsteen basepair]]
[[Category: Hoogsteen basepair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:34:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:57:25 2008''

Revision as of 23:57, 28 July 2008

Image:1xvr.png

Template:STRUCTURE 1xvr

echinomycin (CGTACG)2 complex

Template:ABSTRACT PUBMED 15805599

About this Structure

Full crystallographic information is available from OCA.

Reference

Structures of complexes between echinomycin and duplex DNA., Cuesta-Seijo JA, Sheldrick GM, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):442-8. Epub 2005, Mar 24. PMID:15805599

Page seeded by OCA on Tue Jul 29 02:57:25 2008

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