1xwv

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[[Image:1xwv.gif|left|200px]]
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{{Seed}}
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[[Image:1xwv.png|left|200px]]
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{{STRUCTURE_1xwv| PDB=1xwv | SCENE= }}
{{STRUCTURE_1xwv| PDB=1xwv | SCENE= }}
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'''Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity'''
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===Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity===
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==Overview==
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The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.
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The line below this paragraph, {{ABSTRACT_PUBMED_15710415}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15710415 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15710415}}
==About this Structure==
==About this Structure==
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[[Category: Spangfort, M.]]
[[Category: Spangfort, M.]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:36:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:43:30 2008''

Revision as of 23:43, 27 July 2008

Image:1xwv.png

Template:STRUCTURE 1xwv

Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity

Template:ABSTRACT PUBMED 15710415

About this Structure

1XWV is a Single protein structure of sequence from Dermatophagoides farinae. Full crystallographic information is available from OCA.

Reference

Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity., Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M, FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415

Page seeded by OCA on Mon Jul 28 02:43:30 2008

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