1xyn

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{{STRUCTURE_1xyn| PDB=1xyn | SCENE= }}
{{STRUCTURE_1xyn| PDB=1xyn | SCENE= }}
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'''STRUCTURAL COMPARISON OF TWO MAJOR ENDO-1,4-BETA-XYLANASES FROM TRICHODREMA REESEI'''
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===STRUCTURAL COMPARISON OF TWO MAJOR ENDO-1,4-BETA-XYLANASES FROM TRICHODREMA REESEI===
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==Overview==
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Three-dimensional structures of two major endo-1,4-xylanases, XYNI and XYNII from Trichoderma reesei, have been determined by X-ray crystallography. The amino acid sequences of both enzymes are highly homologous (identity approximately 50%), and both XYNI and XYNII exist as a single domain that contains two mostly antiparallel beta-sheets which are packed against each other. The beta-sheet structure is twisted, forming a cleft where the active site is situated. Two glutamic acids in the cleft, Glu75 and Glu164 in XYNI as well as Glu86 and Glu177 in XYNII, are most likely involved in catalysis. Inspection of the structures reveals that the width of the active site cleft and the number of subsites are different in XYNI and XYNII. The active site is narrower in XYNI and probably contains only three subsites, whereas the number of subsites in XYNII is most likely five. Variations in the surroundings of catalytic residue Glu164XYNI/Glu177XYNII are thought to explain the pH optimum differences observed in XYNI and XYNII.
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(as it appears on PubMed at http://www.pubmed.gov), where 7827044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7827044}}
==About this Structure==
==About this Structure==
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[[Category: Torronen, A.]]
[[Category: Torronen, A.]]
[[Category: Xylanase]]
[[Category: Xylanase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:40:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:40:35 2008''

Revision as of 13:40, 28 July 2008

Image:1xyn.png

Template:STRUCTURE 1xyn

STRUCTURAL COMPARISON OF TWO MAJOR ENDO-1,4-BETA-XYLANASES FROM TRICHODREMA REESEI

Template:ABSTRACT PUBMED 7827044

About this Structure

1XYN is a Single protein structure of sequence from Hypocrea jecorina. Full crystallographic information is available from OCA.

Reference

Structural comparison of two major endo-1,4-xylanases from Trichoderma reesei., Torronen A, Rouvinen J, Biochemistry. 1995 Jan 24;34(3):847-56. PMID:7827044

Page seeded by OCA on Mon Jul 28 16:40:35 2008

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