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1xyr

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{{STRUCTURE_1xyr| PDB=1xyr | SCENE= }}
{{STRUCTURE_1xyr| PDB=1xyr | SCENE= }}
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'''Poliovirus 135S cell entry intermediate'''
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===Poliovirus 135S cell entry intermediate===
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==Overview==
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Poliovirus provides a well-characterized system for understanding how nonenveloped viruses enter and infect cells. Upon binding its receptor, poliovirus undergoes an irreversible conformational change to the 135S cell entry intermediate. This transition involves shifts of the capsid protein beta barrels, accompanied by the externalization of VP4 and the N terminus of VP1. Both polypeptides associate with membranes and are postulated to facilitate entry by forming a translocation pore for the viral RNA. We have calculated cryo-electron microscopic reconstructions of 135S particles that permit accurate placement of the beta barrels, loops, and terminal extensions of the capsid proteins. The reconstructions and resulting models indicate that each N terminus of VP1 exits the capsid though an opening in the interface between VP1 and VP3 at the base of the canyon that surrounds the fivefold axis. Comparison with reconstructions of 135S particles in which the first 31 residues of VP1 were proteolytically removed revealed that the externalized N terminus is located near the tips of propeller-like features surrounding the threefold axes rather than at the fivefold axes, as had been proposed in previous models. These observations have forced a reexamination of current models for the role of the 135S particle in transmembrane pore formation and suggest testable alternatives.
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The line below this paragraph, {{ABSTRACT_PUBMED_15919927}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15919927 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15919927}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Viral capsid]]
[[Category: Viral capsid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:40:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:52:25 2008''

Revision as of 05:52, 29 July 2008

Image:1xyr.png

Template:STRUCTURE 1xyr

Poliovirus 135S cell entry intermediate

Template:ABSTRACT PUBMED 15919927

About this Structure

1XYR is a Protein complex structure of sequences from Human poliovirus 1. Full crystallographic information is available from OCA.

Reference

The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes., Bubeck D, Filman DJ, Cheng N, Steven AC, Hogle JM, Belnap DM, J Virol. 2005 Jun;79(12):7745-55. PMID:15919927

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