1xz0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xz0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xz0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xz0| PDB=1xz0 | SCENE= }}
{{STRUCTURE_1xz0| PDB=1xz0 | SCENE= }}
-
'''Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide'''
+
===Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide===
-
==Overview==
+
<!--
-
CD1a is expressed on Langerhans cells (LCs) and dendritic cells (DCs), where it mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains. We demonstrate here that CD1a-restricted T cells can discriminate the peptide component of didehydroxymycobactin lipopeptides. Structure analysis of CD1a cocrystallized with a synthetic mycobactin lipopeptide at 2.8 A resolution further reveals that the single alkyl chain is inserted deep within the A' pocket of the groove, whereas its two peptidic branches protrude along the F' pocket to the outer, alpha-helical surface of CD1a for recognition by the TCR. Remarkably, the cyclized lysine branch of the peptide moiety lies in the shallow F' pocket in a conformation that closely mimics that of the alkyl chain in the CD1a-sulfatide structure. Thus, this structural study illustrates how a single chain lipid can be presented by CD1 and that the peptide moiety of the lipopeptide is recognized by the TCR.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15723809}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15723809 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15723809}}
==Disease==
==Disease==
Line 38: Line 42:
[[Category: Mhc-fold]]
[[Category: Mhc-fold]]
[[Category: Protein-lipopeptide complex]]
[[Category: Protein-lipopeptide complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:41:04 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:15:29 2008''

Revision as of 11:15, 28 July 2008

Image:1xz0.png

Template:STRUCTURE 1xz0

Contents

Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide

Template:ABSTRACT PUBMED 15723809

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1XZ0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular mechanism of lipopeptide presentation by CD1a., Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA, Immunity. 2005 Feb;22(2):209-19. PMID:15723809

Page seeded by OCA on Mon Jul 28 14:15:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xz0"
Personal tools