1xzy

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[[Image:1xzy.jpg|left|200px]]
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{{Seed}}
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[[Image:1xzy.png|left|200px]]
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{{STRUCTURE_1xzy| PDB=1xzy | SCENE= }}
{{STRUCTURE_1xzy| PDB=1xzy | SCENE= }}
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'''Solution structure of the P30-trans form of Alpha Hemoglobin Stabilizing Protein (AHSP)'''
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===Solution structure of the P30-trans form of Alpha Hemoglobin Stabilizing Protein (AHSP)===
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==Overview==
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Hemoglobin A (HbA), the oxygen delivery system in humans, comprises two alpha and two beta subunits. Free alpha-hemoglobin (alphaHb) is unstable, and its precipitation contributes to the pathophysiology of beta thalassemia. In erythrocytes, the alpha-hemoglobin stabilizing protein (AHSP) binds alphaHb and inhibits its precipitation. The crystal structure of AHSP bound to Fe(II)-alphaHb reveals that AHSP specifically recognizes the G and H helices of alphaHb through a hydrophobic interface that largely recapitulates the alpha1-beta1 interface of hemoglobin. The AHSP-alphaHb interactions are extensive but suboptimal, explaining why beta-hemoglobin can competitively displace AHSP to form HbA. Remarkably, the Fe(II)-heme group in AHSP bound alphaHb is coordinated by the distal but not the proximal histidine. Importantly, binding to AHSP facilitates the conversion of oxy-alphaHb to a deoxygenated, oxidized [Fe(III)], nonreactive form in which all six coordinate positions are occupied. These observations reveal the molecular mechanisms by which AHSP stabilizes free alphaHb.
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The line below this paragraph, {{ABSTRACT_PUBMED_15550245}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15550245 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15550245}}
==About this Structure==
==About this Structure==
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1XZY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XZY OCA].
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1XZY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XZY OCA].
==Reference==
==Reference==
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[[Category: Helical bundle]]
[[Category: Helical bundle]]
[[Category: Three-helix bundle]]
[[Category: Three-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:42:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:15:23 2008''

Revision as of 20:15, 28 July 2008

Image:1xzy.png

Template:STRUCTURE 1xzy

Solution structure of the P30-trans form of Alpha Hemoglobin Stabilizing Protein (AHSP)

Template:ABSTRACT PUBMED 15550245

About this Structure

1XZY is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin., Feng L, Gell DA, Zhou S, Gu L, Kong Y, Li J, Hu M, Yan N, Lee C, Rich AM, Armstrong RS, Lay PA, Gow AJ, Weiss MJ, Mackay JP, Shi Y, Cell. 2004 Nov 24;119(5):629-40. PMID:15550245

Page seeded by OCA on Mon Jul 28 23:15:23 2008

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