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1y07

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[[Image:1y07.gif|left|200px]]
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{{STRUCTURE_1y07| PDB=1y07 | SCENE= }}
{{STRUCTURE_1y07| PDB=1y07 | SCENE= }}
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'''Crystal structure of the superoxide reductase from Treponema pallidum'''
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===Crystal structure of the superoxide reductase from Treponema pallidum===
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==Overview==
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Superoxide reductase (SOR) is a metalloprotein containing a non-heme iron centre, responsible for the scavenging of superoxide radicals in the cell. The crystal structure of Treponema pallidum (Tp) SOR was determined using soft X-rays and synchrotron radiation. Crystals of the oxidized form were obtained using poly(ethylene glycol) and MgCl2 and diffracted beyond 1.55 A resolution. The overall architecture is very similar to that of other known SORs but TpSOR contains an N-terminal domain in which the desulforedoxin-type Fe centre, found in other SORs, is absent. This domain conserves the beta-barrel topology with an overall arrangement very similar to that of other SOR proteins where the centre is present. The absence of the iron ion and its ligands, however, causes a decrease in the cohesion of the domain and some disorder is observed, particularly in the region where the metal would be harboured. The C-terminal domain exhibits the characteristic immunoglobulin-like fold and harbours the Fe(His)4(Cys) active site. The five ligands of the iron centre are well conserved despite some disorder observed for one of the four molecules in the asymmetric unit. The participation of a glutamate as the sixth ligand of some of the iron centres in Pyrococcus furiosus SOR was not observed in TpSOR. A possible explanation is that either X-ray photoreduction occurred or there was a mixture of redox states at the start of data collection. In agreement with earlier proposals, details in the TpSOR structure also suggest that Lys49 might be involved in attraction of superoxide to the active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 16791639 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16791639}}
==About this Structure==
==About this Structure==
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[[Category: Beta-sheet]]
[[Category: Beta-sheet]]
[[Category: Iron binding]]
[[Category: Iron binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:08:12 2008''

Revision as of 06:08, 29 July 2008

Image:1y07.png

Template:STRUCTURE 1y07

Crystal structure of the superoxide reductase from Treponema pallidum

Template:ABSTRACT PUBMED 16791639

About this Structure

1Y07 is a Single protein structure of sequence from Treponema pallidum subsp. pallidum str. nichols. Full crystallographic information is available from OCA.

Reference

The first crystal structure of class III superoxide reductase from Treponema pallidum., Santos-Silva T, Trincao J, Carvalho AL, Bonifacio C, Auchere F, Raleiras P, Moura I, Moura JJ, Romao MJ, J Biol Inorg Chem. 2006 Jul;11(5):548-58. Epub 2006 May 6. PMID:16791639

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