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1y0f

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{{STRUCTURE_1y0f| PDB=1y0f | SCENE= }}
{{STRUCTURE_1y0f| PDB=1y0f | SCENE= }}
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'''The structure of collagen type I. Single type I collagen molecule'''
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===The structure of collagen type I. Single type I collagen molecule===
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==Overview==
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The fibrous collagens are ubiquitous in animals and form the structural basis of all mammalian connective tissues, including those of the heart, vasculature, skin, cornea, bones, and tendons. However, in comparison with what is known of their production, turnover and physiological structure, very little is understood regarding the three-dimensional arrangement of collagen molecules in naturally occurring fibrils. This knowledge may provide insight into key biological processes such as fibrillo-genesis and tissue remodeling and into diseases such as heart disease and cancer. Here we present a crystallographic determination of the collagen type I supermolecular structure, where the molecular conformation of each collagen segment found within the naturally occurring crystallographic unit cell has been defined (P1, a approximately 40.0 A, b approximately 27.0 A, c approximately 678 A, alpha approximately 89.2 degrees , beta approximately 94.6 degrees , gamma approximately 105.6 degrees ; reflections: 414, overlapping, 232, and nonoverlapping, 182; resolution, 5.16 A axial and 11.1 A equatorial). This structure shows that the molecular packing topology of the collagen molecule is such that packing neighbors are arranged to form a supertwisted (discontinuous) right-handed microfibril that interdigitates with neighboring microfibrils. This interdigitation establishes the crystallographic superlattice, which is formed of quasihexagonally packed collagen molecules. In addition, the molecular packing structure of collagen shown here provides information concerning the potential modes of action of two prominent molecules involved in human health and disease: decorin and the Matrix Metallo-Proteinase (MMP) collagenase.
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(as it appears on PubMed at http://www.pubmed.gov), where 16751282 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16751282}}
==About this Structure==
==About this Structure==
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[[Category: Supermolecular]]
[[Category: Supermolecular]]
[[Category: Triple-helix]]
[[Category: Triple-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:43:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:45:12 2008''

Revision as of 21:45, 28 July 2008

Image:1y0f.png

Template:STRUCTURE 1y0f

The structure of collagen type I. Single type I collagen molecule

Template:ABSTRACT PUBMED 16751282

About this Structure

1Y0F is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Microfibrillar structure of type I collagen in situ., Orgel JP, Irving TC, Miller A, Wess TJ, Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9001-5. Epub 2006 Jun 2. PMID:16751282

Page seeded by OCA on Tue Jul 29 00:45:12 2008

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