1y12

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{{STRUCTURE_1y12| PDB=1y12 | SCENE= }}
{{STRUCTURE_1y12| PDB=1y12 | SCENE= }}
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'''Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa'''
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===Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa===
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==Overview==
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Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 16763151 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16763151}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:45:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:45:35 2008''

Revision as of 11:45, 29 July 2008

Image:1y12.png

Template:STRUCTURE 1y12

Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa

Template:ABSTRACT PUBMED 16763151

About this Structure

1Y12 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus., Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ, Science. 2006 Jun 9;312(5779):1526-30. PMID:16763151

Page seeded by OCA on Tue Jul 29 14:45:35 2008

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