This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1y27

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1y27.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1y27.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1y27| PDB=1y27 | SCENE= }}
{{STRUCTURE_1y27| PDB=1y27 | SCENE= }}
-
'''G-riboswitch-guanine complex'''
+
===G-riboswitch-guanine complex===
-
==Overview==
+
<!--
-
Metabolite-sensing mRNAs, or "riboswitches," specifically interact with small ligands and direct expression of the genes involved in their metabolism. Riboswitches contain sensing "aptamer" modules, capable of ligand-induced structural changes, and downstream regions, harboring expression-controlling elements. We report the crystal structures of the add A-riboswitch and xpt G-riboswitch aptamer modules that distinguish between bound adenine and guanine with exquisite specificity and modulate expression of two different sets of genes. The riboswitches form tuning fork-like architectures, in which the prongs are held in parallel through hairpin loop interactions, and the internal bubble zippers up to form the purine binding pocket. The bound purines are held by hydrogen bonding interactions involving conserved nucleotides along their entire periphery. Recognition specificity is associated with Watson-Crick pairing of the encapsulated adenine and guanine ligands with uridine and cytosine, respectively.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15610857}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15610857 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15610857}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Crystal structure]]
[[Category: Crystal structure]]
[[Category: G-riboswitch guanine recognition]]
[[Category: G-riboswitch guanine recognition]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:47:39 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:04:22 2008''

Revision as of 12:04, 29 July 2008

Image:1y27.png

Template:STRUCTURE 1y27

G-riboswitch-guanine complex

Template:ABSTRACT PUBMED 15610857

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs., Serganov A, Yuan YR, Pikovskaya O, Polonskaia A, Malinina L, Phan AT, Hobartner C, Micura R, Breaker RR, Patel DJ, Chem Biol. 2004 Dec;11(12):1729-41. PMID:15610857

Page seeded by OCA on Tue Jul 29 15:04:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y27"
Personal tools