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1y3a

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{{STRUCTURE_1y3a| PDB=1y3a | SCENE= }}
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'''Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange'''
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===Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange===
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==Overview==
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Heterotrimeric G proteins are molecular switches that regulate numerous signaling pathways involved in cellular physiology. This characteristic is achieved by the adoption of two principal states: an inactive, GDP bound state and an active, GTP bound state. Under basal conditions, G proteins exist in the inactive, GDP bound state; thus, nucleotide exchange is crucial to the onset of signaling. Despite our understanding of G protein signaling pathways, the mechanism of nucleotide exchange remains elusive. We employed phage display technology to identify nucleotide state-dependent Galpha binding peptides. Herein, we report a GDP-selective Galpha binding peptide, KB-752, that enhances spontaneous nucleotide exchange of Galpha(i) subunits. Structural determination of the Galpha(i1)/peptide complex reveals unique changes in the Galpha switch regions predicted to enhance nucleotide exchange by creating a GDP dissociation route. Our results cast light onto a potential mechanism by which Galpha subunits adopt a conformation suitable for nucleotide exchange.
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(as it appears on PubMed at http://www.pubmed.gov), where 16004878 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16004878}}
==About this Structure==
==About this Structure==
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[[Category: Willard, F S.]]
[[Category: Willard, F S.]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:49:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:58:33 2008''

Revision as of 12:58, 27 July 2008

Image:1y3a.png

Template:STRUCTURE 1y3a

Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

Template:ABSTRACT PUBMED 16004878

About this Structure

1Y3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange., Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP, Structure. 2005 Jul;13(7):1069-80. PMID:16004878

Page seeded by OCA on Sun Jul 27 15:58:33 2008

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