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1ya3

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{{STRUCTURE_1ya3| PDB=1ya3 | SCENE= }}
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'''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension'''
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===Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension===
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==Overview==
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The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.
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(as it appears on PubMed at http://www.pubmed.gov), where 15908963 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15908963}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear receptor transcription regulation]]
[[Category: Nuclear receptor transcription regulation]]
[[Category: Steroid receptor]]
[[Category: Steroid receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:03:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:50:39 2008''

Revision as of 19:50, 27 July 2008

Image:1ya3.png

Template:STRUCTURE 1ya3

Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension

Template:ABSTRACT PUBMED 15908963

About this Structure

1YA3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension., Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin ME, Nat Struct Mol Biol. 2005 Jun;12(6):554-5. Epub 2005 May 22. PMID:15908963

Page seeded by OCA on Sun Jul 27 22:50:39 2008

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