1yc6

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{{STRUCTURE_1yc6| PDB=1yc6 | SCENE= }}
{{STRUCTURE_1yc6| PDB=1yc6 | SCENE= }}
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'''Crystallographic Structure of the T=1 Particle of Brome Mosaic Virus'''
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===Crystallographic Structure of the T=1 Particle of Brome Mosaic Virus===
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==Overview==
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T=1 icosahedral particles of amino terminally truncated brome mosaic virus (BMV) protein were created by treatment of the wild-type T=3 virus with 1M CaCl2 and crystallized from sodium malonate. Diffraction data were collected from frozen crystals to beyond 2.9 A resolution and the structure determined by molecular replacement and phase extension. The particles are composed of pentameric capsomeres from the wild-type virions which have reoriented with respect to the original particle pentameric axes by rotations of 37 degrees , and formed tenuous interactions with one another, principally through conformationally altered C-terminal polypeptides. Otherwise, the pentamers are virtually superimposable upon those of the original T=3 BMV particles. The T=1 particles, in the crystals, are not perfect icosahedra, but deviate slightly from exact symmetry, possibly due to packing interactions. This suggests that the T=1 particles are deformable, which is consistent with the loose arrangement of pentamers and latticework of holes that penetrate the surface. Atomic force microscopy showed that the T=3 to T=1 transition could occur by shedding of hexameric capsomeres and restructuring of remaining pentamers accompanied by direct condensation. Knowledge of the structures of the BMV wild-type and T=1 particles now permit us to propose a tentative model for that process. A comparison of the BMV T=1 particles was made with the reassembled T=1 particles produced from the coat protein of trypsin treated alfalfa mosaic virus (AlMV), another bromovirus. There is little resemblance between the two particles. The BMV particle, with a maximum diameter of 195 A, is made from distinctive pentameric capsomeres with large holes along the 3-fold axis, while the AlMV particle, of approximate maximum diameter 220 A, has subunits closely packed around the 3-fold axis, large holes along the 5-fold axis, and few contacts within pentamers. In both particles crucial linkages are made about icosahedral dyads.
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(as it appears on PubMed at http://www.pubmed.gov), where 15713465 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15713465}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystallographic structure of the T=1 particle of brome mosaic virus., Larson SB, Lucas RW, McPherson A, J Mol Biol. 2005 Feb 25;346(3):815-31. Epub 2005 Jan 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15713465 15713465]
Crystallographic structure of the T=1 particle of brome mosaic virus., Larson SB, Lucas RW, McPherson A, J Mol Biol. 2005 Feb 25;346(3):815-31. Epub 2005 Jan 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15713465 15713465]
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The crystallographic structure of brome mosaic virus., Lucas RW, Larson SB, McPherson A, J Mol Biol. 2002 Mar 15;317(1):95-108. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11916381 11916381]
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Crystallization of Brome mosaic virus and T = 1 Brome mosaic virus particles following a structural transition., Lucas RW, Kuznetsov YG, Larson SB, McPherson A, Virology. 2001 Aug 1;286(2):290-303. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11485397 11485397]
[[Category: Brome mosaic virus]]
[[Category: Brome mosaic virus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Structural transition]]
[[Category: Structural transition]]
[[Category: Symmetry]]
[[Category: Symmetry]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:08:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:56:03 2008''

Revision as of 08:56, 28 July 2008

Image:1yc6.png

Template:STRUCTURE 1yc6

Crystallographic Structure of the T=1 Particle of Brome Mosaic Virus

Template:ABSTRACT PUBMED 15713465

About this Structure

1YC6 is a Single protein structure of sequence from Brome mosaic virus. Full crystallographic information is available from OCA.

Reference

Crystallographic structure of the T=1 particle of brome mosaic virus., Larson SB, Lucas RW, McPherson A, J Mol Biol. 2005 Feb 25;346(3):815-31. Epub 2005 Jan 12. PMID:15713465

The crystallographic structure of brome mosaic virus., Lucas RW, Larson SB, McPherson A, J Mol Biol. 2002 Mar 15;317(1):95-108. PMID:11916381

Crystallization of Brome mosaic virus and T = 1 Brome mosaic virus particles following a structural transition., Lucas RW, Kuznetsov YG, Larson SB, McPherson A, Virology. 2001 Aug 1;286(2):290-303. PMID:11485397

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