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1ycj

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[[Image:1ycj.gif|left|200px]]
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{{Seed}}
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[[Image:1ycj.png|left|200px]]
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{{STRUCTURE_1ycj| PDB=1ycj | SCENE= }}
{{STRUCTURE_1ycj| PDB=1ycj | SCENE= }}
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'''Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate'''
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===Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate===
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==Overview==
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The X-ray structure of the ligand-binding core of the kainate receptor GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A resolution. The overall GluR5-S1S2 structure comprises two domains and is similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as in GluR2-S1S2J. Distinct features are observed for Ser741, which stabilizes a highly coordinated network of water molecules and forms an interdomain bridge. The GluR5 complex exhibits a high degree of domain closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2 forms a novel dimer interface with a different arrangement of the two protomers compared to GluR2-S1S2J.
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The line below this paragraph, {{ABSTRACT_PUBMED_15710405}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15710405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15710405}}
==About this Structure==
==About this Structure==
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[[Category: Ionotropic glutamate receptor]]
[[Category: Ionotropic glutamate receptor]]
[[Category: Kainate receptor]]
[[Category: Kainate receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:09:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:10:36 2008''

Revision as of 21:10, 27 July 2008

Image:1ycj.png

Template:STRUCTURE 1ycj

Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

Template:ABSTRACT PUBMED 15710405

About this Structure

1YCJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate., Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS, FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405

Page seeded by OCA on Mon Jul 28 00:10:36 2008

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