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1yeg

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{{STRUCTURE_1yeg| PDB=1yeg | SCENE= }}
{{STRUCTURE_1yeg| PDB=1yeg | SCENE= }}
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'''STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT'''
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===STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT===
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==Overview==
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The x-ray structures of the unliganded esterase-like catalytic antibody D2.3 and its complexes with a substrate analogue and with one of the reaction products are analyzed. Together with the structure of the phosphonate transition state analogue hapten complex, these crystal structures provide a complete description of the reaction pathway. At alkaline pH, D2.3 acts by preferential stabilization of the negatively charged oxyanion intermediate of the reaction that results from hydroxide attack on the substrate. A tyrosine residue plays a crucial role in catalysis: it activates the ester substrate and, together with an asparagine, it stabilizes the oxyanion intermediate. A canal allows facile diffusion of water molecules to the reaction center that is deeply buried in the structure. Residues bordering this canal provide targets for mutagenesis to introduce a general base in the vicinity of the reaction center.
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(as it appears on PubMed at http://www.pubmed.gov), where 9223277 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9223277}}
==About this Structure==
==About this Structure==
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[[Category: Knossow, M.]]
[[Category: Knossow, M.]]
[[Category: Catalytic antibody]]
[[Category: Catalytic antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:13:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:00:23 2008''

Revision as of 23:00, 27 July 2008

Image:1yeg.png

Template:STRUCTURE 1yeg

STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT

Template:ABSTRACT PUBMED 9223277

About this Structure

1YEG is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release., Gigant B, Charbonnier JB, Eshhar Z, Green BS, Knossow M, Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7857-61. PMID:9223277

Page seeded by OCA on Mon Jul 28 02:00:23 2008

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