1yf4

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{{STRUCTURE_1yf4| PDB=1yf4 | SCENE= }}
{{STRUCTURE_1yf4| PDB=1yf4 | SCENE= }}
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'''Crystal Structure of trypsin-vasopressin complex'''
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===Crystal Structure of trypsin-vasopressin complex===
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==Overview==
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The large variety of serine protease inhibitors, available from various sources such as tissues, microorganisms, plants, etc., play an important role in regulating the proteolytic enzymes. The analysis of protease-inhibitor complexes helps in understanding the mechanism of action, as well as in designing inhibitors. Vasopressin, an anti-diuretic nonapeptide hormone, is found to be an effective inhibitor of trypsin, with a K(i) value of 5 nM. The crystal structure of the trypsin-vasopressin complex revealed that vasopressin fulfils all the important interactions for an inhibitor, without any break in the scissile peptide bond. The cyclic nature due to a disulfide bridge between Cys1 and Cys6 of vasopressin provides structural rigidity to the peptide hormone. The trypsin-binding site is located at the C terminus, while the neurophysin-binding site is at the N terminus of vasopressin. This study will assist in designing new peptide inhibitors. This study suggests that vasopressin inhibition of trypsin may have unexplored biological implications.
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(as it appears on PubMed at http://www.pubmed.gov), where 15854654 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15854654}}
==About this Structure==
==About this Structure==
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[[Category: Trypsin]]
[[Category: Trypsin]]
[[Category: Vasopressin]]
[[Category: Vasopressin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:02:57 2008''

Revision as of 03:03, 29 July 2008

Image:1yf4.png

Template:STRUCTURE 1yf4

Crystal Structure of trypsin-vasopressin complex

Template:ABSTRACT PUBMED 15854654

About this Structure

1YF4 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Trypsin inhibition by a peptide hormone: crystal structure of trypsin-vasopressin complex., Syed Ibrahim B, Pattabhi V, J Mol Biol. 2005 May 20;348(5):1191-8. Epub 2005 Apr 1. PMID:15854654

Page seeded by OCA on Tue Jul 29 06:02:57 2008

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