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1yh0

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{{STRUCTURE_1yh0| PDB=1yh0 | SCENE= }}
{{STRUCTURE_1yh0| PDB=1yh0 | SCENE= }}
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'''Crystal Structure of Acetylornithine Transcarbamylase'''
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===Crystal Structure of Acetylornithine Transcarbamylase===
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==Overview==
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We have identified in Xanthomonas campestris a novel N-acetylornithine transcarbamylase that replaces ornithine transcarbamylase in the canonic arginine biosynthetic pathway of several Eubacteria. The crystal structures of the protein in the presence and absence of the reaction product, N-acetylcitrulline, were determined. This new family of transcarbamylases lacks the DxxSMG motif that is characteristic of all ornithine transcarbamylases (OTCases) and contains a novel proline-rich loop that forms part of the active site. The specificity for N-acetylornithine is conferred by hydrogen bonding with residues in the proline-rich loop via water molecules and by hydrophobic interactions with residues from the adjacent 80's, 120's, and proline-rich loops. This novel protein structure provides a starting point for rational design of specific analogs that may be useful in combating human and plant pathogens that utilize acetylornithine transcarbamylase rather than ornithine transcarbamylase.
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(as it appears on PubMed at http://www.pubmed.gov), where 15731101 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15731101}}
==About this Structure==
==About this Structure==
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[[Category: Argf]]
[[Category: Argf]]
[[Category: Transcarbamylase]]
[[Category: Transcarbamylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:18:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:39:51 2008''

Revision as of 12:39, 28 July 2008

Image:1yh0.png

Template:STRUCTURE 1yh0

Crystal Structure of Acetylornithine Transcarbamylase

Template:ABSTRACT PUBMED 15731101

About this Structure

1YH0 is a Single protein structure of sequence from Xanthomonas campestris. Full crystallographic information is available from OCA.

Reference

Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria., Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M, J Biol Chem. 2005 Apr 15;280(15):14366-9. Epub 2005 Feb 24. PMID:15731101

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