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1yi5

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[[Image:1yi5.gif|left|200px]]
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[[Image:1yi5.png|left|200px]]
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==Overview==
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{{ABSTRACT_15791209}}
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The crystal structure of the snake long alpha-neurotoxin, alpha-cobratoxin, bound to the pentameric acetylcholine-binding protein (AChBP) from Lymnaea stagnalis, was solved from good quality density maps despite a 4.2 A overall resolution. The structure unambiguously reveals the positions and orientations of all five three-fingered toxin molecules inserted at the AChBP subunit interfaces and the conformational changes associated with toxin binding. AChBP loops C and F that border the ligand-binding pocket move markedly from their original positions to wrap around the tips of the toxin first and second fingers and part of its C-terminus, while rearrangements also occur in the toxin fingers. At the interface of the complex, major interactions involve aromatic and aliphatic side chains within the AChBP binding pocket and, at the buried tip of the toxin second finger, conserved Phe and Arg residues that partially mimic a bound agonist molecule. Hence this structure, in revealing a distinctive and unpredicted conformation of the toxin-bound AChBP molecule, provides a lead template resembling a resting state conformation of the nicotinic receptor and for understanding selectivity of curaremimetic alpha-neurotoxins for the various receptor species.
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==About this Structure==
==About this Structure==
1YI5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis] and [http://en.wikipedia.org/wiki/Naja_siamensis Naja siamensis]. The following page contains interesting information on the relation of 1YI5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb71_1.html Acetylcholine Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YI5 OCA].
1YI5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis] and [http://en.wikipedia.org/wiki/Naja_siamensis Naja siamensis]. The following page contains interesting information on the relation of 1YI5 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb71_1.html Acetylcholine Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YI5 OCA].
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==Reference==
 
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Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors., Bourne Y, Talley TT, Hansen SB, Taylor P, Marchot P, EMBO J. 2005 Apr 20;24(8):1512-22. Epub 2005 Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15791209 15791209]
 
[[Category: Acetylcholine Receptor]]
[[Category: Acetylcholine Receptor]]
[[Category: Lymnaea stagnalis]]
[[Category: Lymnaea stagnalis]]
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[[Category: Crystal structure]]
[[Category: Crystal structure]]
[[Category: Snake three-fingered alpha-neurotoxin]]
[[Category: Snake three-fingered alpha-neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:20:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:08:24 2008''

Revision as of 15:08, 26 June 2008

Image:1yi5.png

Template:STRUCTURE 1yi5

Crystal structure of the a-cobratoxin-AChBP complex


Template:ABSTRACT 15791209

About this Structure

1YI5 is a Protein complex structure of sequences from Lymnaea stagnalis and Naja siamensis. The following page contains interesting information on the relation of 1YI5 with [Acetylcholine Receptor]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:08:24 2008

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OCA

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