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1ymg

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{{STRUCTURE_1ymg| PDB=1ymg | SCENE= }}
{{STRUCTURE_1ymg| PDB=1ymg | SCENE= }}
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'''The Channel Architecture of Aquaporin O at 2.2 Angstrom Resolution'''
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===The Channel Architecture of Aquaporin O at 2.2 Angstrom Resolution===
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==Overview==
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We determined the x-ray structure of bovine aquaporin 0 (AQP0) to a resolution of 2.2 A. The structure of this eukaryotic, integral membrane protein suggests that the selectivity of AQP0 for water transport is based on the identity and location of signature amino acid residues that are hallmarks of the water-selective arm of the AQP family of proteins. Furthermore, the channel lumen is narrowed only by two, quasi-2-fold related tyrosine side chains that might account for reduced water conductance relative to other AQPs. The channel is functionally open to the passage of water because there are eight discreet water molecules within the channel. Comparison of this structure with the recent electron-diffraction structure of the junctional form of sheep AQP0 at pH 6.0 that was interpreted as closed shows no global change in the structure of AQP0 and only small changes in side-chain positions. We observed no structural change to the channel or the molecule as a whole at pH 10, which could be interpreted as the postulated pH-gating mechanism of AQP0-mediated water transport at pH &gt;6.5. Contrary to the electron-diffraction structure, the comparison shows no evidence of channel gating induced by association of the extracellular domains of AQP0 at pH 6.0. Our structure aids the analysis of the interaction of the extracellular domains and the possibility of a cell-cell adhesion role for AQP0. In addition, our structure illustrates the basis for formation of certain types of cataracts that are the result of mutations.
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{{ABSTRACT_PUBMED_15377788}}
==About this Structure==
==About this Structure==
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[[Category: Mip26]]
[[Category: Mip26]]
[[Category: Water channel]]
[[Category: Water channel]]
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Revision as of 08:24, 29 July 2008

Image:1ymg.png

Template:STRUCTURE 1ymg

The Channel Architecture of Aquaporin O at 2.2 Angstrom Resolution

Template:ABSTRACT PUBMED 15377788

About this Structure

1YMG is a Single protein structure of sequence from Bos taurus. This structure supersedes the now removed PDB entry 1tm8. Full crystallographic information is available from OCA.

Reference

The channel architecture of aquaporin 0 at a 2.2-A resolution., Harries WE, Akhavan D, Miercke LJ, Khademi S, Stroud RM, Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14045-50. Epub 2004 Sep 17. PMID:15377788

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