1yo8

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{{STRUCTURE_1yo8| PDB=1yo8 | SCENE= }}
{{STRUCTURE_1yo8| PDB=1yo8 | SCENE= }}
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'''Strucuture of the C-terminal domain of human thrombospondin-2'''
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===Strucuture of the C-terminal domain of human thrombospondin-2===
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==Overview==
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Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2+) ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease.
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(as it appears on PubMed at http://www.pubmed.gov), where 16186819 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16186819}}
==About this Structure==
==About this Structure==
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[[Category: Egf]]
[[Category: Egf]]
[[Category: Lectin domain]]
[[Category: Lectin domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:34:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:25:58 2008''

Revision as of 03:26, 28 July 2008

Image:1yo8.png

Template:STRUCTURE 1yo8

Strucuture of the C-terminal domain of human thrombospondin-2

Template:ABSTRACT PUBMED 16186819

About this Structure

1YO8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the calcium-rich signature domain of human thrombospondin-2., Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL, Nat Struct Mol Biol. 2005 Oct;12(10):910-4. Epub 2005 Sep 25. PMID:16186819

Page seeded by OCA on Mon Jul 28 06:25:58 2008

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