1yp8

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[[Image:1yp8.gif|left|200px]]
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{{Seed}}
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[[Image:1yp8.png|left|200px]]
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{{STRUCTURE_1yp8| PDB=1yp8 | SCENE= }}
{{STRUCTURE_1yp8| PDB=1yp8 | SCENE= }}
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'''Solution structure of the cyclotide tricyclon A'''
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===Solution structure of the cyclotide tricyclon A===
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==Overview==
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Cyclotides are a family of plant proteins that have the unusual combination of head-to-tail backbone cyclization and a cystine knot motif. They are exceptionally stable and show resistance to most chemical, physical, and enzymatic treatments. The structure of tricyclon A, a previously unreported cyclotide, is described here. In this structure, a loop that is disordered in other cyclotides forms a beta sheet that protrudes from the globular core. This study indicates that the cyclotide fold is amenable to the introduction of a range of structural elements without affecting the cystine knot core of the protein, which is essential for the stability of the cyclotides. Tricyclon A does not possess a hydrophobic patch, typical of other cyclotides, and has minimal hemolytic activity, making it suitable for pharmaceutical applications. The 22 kDa precursor protein of tricyclon A was identified and provides clues to the processing of these fascinating miniproteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15893660}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15893660 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15893660}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP8 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP8 OCA].
==Reference==
==Reference==
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[[Category: Cyclotide]]
[[Category: Cyclotide]]
[[Category: Cystine knot]]
[[Category: Cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:36:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:03:45 2008''

Revision as of 02:03, 28 July 2008

Image:1yp8.png

Template:STRUCTURE 1yp8

Solution structure of the cyclotide tricyclon A

Template:ABSTRACT PUBMED 15893660

About this Structure

Full experimental information is available from OCA.

Reference

Processing of a 22 kDa precursor protein to produce the circular protein tricyclon A., Mulvenna JP, Sando L, Craik DJ, Structure. 2005 May;13(5):691-701. PMID:15893660

Page seeded by OCA on Mon Jul 28 05:03:45 2008

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