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1ypp

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[[Image:1ypp.gif|left|200px]]
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{{STRUCTURE_1ypp| PDB=1ypp | SCENE= }}
{{STRUCTURE_1ypp| PDB=1ypp | SCENE= }}
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'''ACID ANHYDRIDE HYDROLASE'''
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===ACID ANHYDRIDE HYDROLASE===
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==Overview==
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The three-dimensional structure of the manganese-phosphate complex of inorganic pyrophosphatase from Saccharomyces cerevisiae has been refined to an R factor of 19.0% at 2.4-A resolution. X-ray data were collected from a single crystal using an imaging plate scanner and synchrotron radiation. There is one dimeric molecule in the asymmetric unit. The upper estimate of the root-mean-square coordinate error is 0.4 A using either the delta A plot or the superposition of the two crystallographically independent subunits. The good agreement between the coordinates of the two subunits, which were not subjected to non-crystallographic symmetry restraints, provides independent validation of the structure analysis. The active site in each subunit contains four manganese ions and two phosphates. The manganese ions are coordinated by the side chains of aspartate and glutamate residues. The phosphate groups, which were identified on the basis of their local stereochemistry, interact either directly or via water molecules with manganese ions and lysine, arginine, and tyrosine side chains. The phosphates are bridged by two of the manganese ions. The outer phosphate is exposed to solvent. The inner phosphate is surrounded by all four manganese ions. The ion-binding sites are related to the order of binding previously established from kinetic studies. A hypothesis for the transition state of the catalytic reaction is put forward.
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(as it appears on PubMed at http://www.pubmed.gov), where 8706712 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8706712}}
==About this Structure==
==About this Structure==
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[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:37:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:26:00 2008''

Revision as of 11:26, 29 July 2008

Image:1ypp.png

Template:STRUCTURE 1ypp

ACID ANHYDRIDE HYDROLASE

Template:ABSTRACT PUBMED 8706712

About this Structure

1YPP is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

X-ray structure of yeast inorganic pyrophosphatase complexed with manganese and phosphate., Harutyunyan EH, Kuranova IP, Vainshtein BK, Hohne WE, Lamzin VS, Dauter Z, Teplyakov AV, Wilson KS, Eur J Biochem. 1996 Jul 1;239(1):220-8. PMID:8706712

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