1ypy

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[[Image:1ypy.gif|left|200px]]
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{{STRUCTURE_1ypy| PDB=1ypy | SCENE= }}
{{STRUCTURE_1ypy| PDB=1ypy | SCENE= }}
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'''Crystal Structure of Vaccinia Virus L1 protein'''
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===Crystal Structure of Vaccinia Virus L1 protein===
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==Overview==
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Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1 protein, a molecule that is conserved throughout the poxvirus family and is nearly identical in vaccinia virus and in variola virus, which causes smallpox. L1 is a myristoylated envelope protein that is a potent target for neutralizing antibodies and an important component of current experimental vaccines. The L1 structure reveals a hydrophobic cavity located adjacent to its N terminus. The cavity would be capable of shielding the myristate moiety, which is essential for virion assembly. The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15761054 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15761054}}
==About this Structure==
==About this Structure==
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[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
[[Category: Variola virus]]
[[Category: Variola virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:54:08 2008''

Revision as of 17:54, 28 July 2008

Image:1ypy.png

Template:STRUCTURE 1ypy

Crystal Structure of Vaccinia Virus L1 protein

Template:ABSTRACT PUBMED 15761054

About this Structure

1YPY is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies., Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN, Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4240-5. Epub 2005 Mar 10. PMID:15761054

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