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1yq4

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[[Image:1yq4.gif|left|200px]]
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{{STRUCTURE_1yq4| PDB=1yq4 | SCENE= }}
{{STRUCTURE_1yq4| PDB=1yq4 | SCENE= }}
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'''Avian respiratory complex ii with 3-nitropropionate and ubiquinone'''
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===Avian respiratory complex ii with 3-nitropropionate and ubiquinone===
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==Overview==
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We report three new structures of mitochondrial respiratory Complex II (succinate ubiquinone oxidoreductase, E.C. 1.3.5.1) at up to 2.1 A resolution, with various inhibitors. The structures define the conformation of the bound inhibitors and suggest the residues involved in substrate binding and catalysis at the dicarboxylate site. In particular they support the role of Arg(297) as a general base catalyst accepting a proton in the dehydrogenation of succinate. The dicarboxylate ligand in oxaloacetate-containing crystals appears to be the same as that reported for Shewanella flavocytochrome c treated with fumarate. The plant and fungal toxin 3-nitropropionic acid, an irreversible inactivator of succinate dehydrogenase, forms a covalent adduct with the side chain of Arg(297). The modification eliminates a trypsin cleavage site in the flavoprotein, and tandem mass spectroscopic analysis of the new fragment shows the mass of Arg(297) to be increased by 83 Da and to have the potential of losing 44 Da, consistent with decarboxylation, during fragmentation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16371358 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16371358}}
==About this Structure==
==About this Structure==
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[[Category: Redox enzyme]]
[[Category: Redox enzyme]]
[[Category: Respiratory chain]]
[[Category: Respiratory chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:38:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:46:56 2008''

Revision as of 06:47, 28 July 2008

Image:1yq4.png

Template:STRUCTURE 1yq4

Avian respiratory complex ii with 3-nitropropionate and ubiquinone

Template:ABSTRACT PUBMED 16371358

About this Structure

1YQ4 is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme., Huang LS, Sun G, Cobessi D, Wang AC, Shen JT, Tung EY, Anderson VE, Berry EA, J Biol Chem. 2006 Mar 3;281(9):5965-72. Epub 2005 Dec 21. PMID:16371358

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