1yq9

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{{STRUCTURE_1yq9| PDB=1yq9 | SCENE= }}
{{STRUCTURE_1yq9| PDB=1yq9 | SCENE= }}
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'''Structure of the unready oxidized form of [NiFe] hydrogenase'''
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===Structure of the unready oxidized form of [NiFe] hydrogenase===
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==Overview==
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[NiFe] hydrogenases catalyze the reversible heterolytic cleavage of molecular hydrogen. Several oxidized, inactive states of these enzymes are known that are distinguishable by their very different activation properties. So far, the structural basis for this difference has not been understood because of lack of relevant crystallographic data. Here, we present the crystal structure of the ready Ni-B state of Desulfovibrio fructosovorans [NiFe] hydrogenase and show it to have a putative mu-hydroxo Ni-Fe bridging ligand at the active site. On the other hand, a new, improved refinement procedure of the X-ray diffraction data obtained for putative unready Ni-A/Ni-SU states resulted in a more elongated electron density for the bridging ligand, suggesting that it is a diatomic species. The slow activation of the Ni-A state, compared with the rapid activation of the Ni-B state, is therefore proposed to result from the different chemical nature of the ligands in the two oxidized species. Our results along with very recent electrochemical studies suggest that the diatomic ligand could be hydro-peroxide.
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The line below this paragraph, {{ABSTRACT_PUBMED_15803334}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15803334 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15803334}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural differences between the ready and unready oxidized states of [NiFe] hydrogenases., Volbeda A, Martin L, Cavazza C, Matho M, Faber BW, Roseboom W, Albracht SP, Garcin E, Rousset M, Fontecilla-Camps JC, J Biol Inorg Chem. 2005 May;10(3):239-49. Epub 2005 Apr 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15803334 15803334]
Structural differences between the ready and unready oxidized states of [NiFe] hydrogenases., Volbeda A, Martin L, Cavazza C, Matho M, Faber BW, Roseboom W, Albracht SP, Garcin E, Rousset M, Fontecilla-Camps JC, J Biol Inorg Chem. 2005 May;10(3):239-49. Epub 2005 Apr 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15803334 15803334]
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Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas., Volbeda A, Charon MH, Piras C, Hatchikian EC, Frey M, Fontecilla-Camps JC, Nature. 1995 Feb 16;373(6515):580-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7854413 7854413]
[[Category: Cytochrome-c3 hydrogenase]]
[[Category: Cytochrome-c3 hydrogenase]]
[[Category: Desulfovibrio gigas]]
[[Category: Desulfovibrio gigas]]
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[[Category: Volbeda, A.]]
[[Category: Volbeda, A.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:38:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:42:12 2008''

Revision as of 12:42, 27 July 2008

Image:1yq9.png

Template:STRUCTURE 1yq9

Structure of the unready oxidized form of [NiFe] hydrogenase

Template:ABSTRACT PUBMED 15803334

About this Structure

1YQ9 is a Protein complex structure of sequences from Desulfovibrio gigas. Full crystallographic information is available from OCA.

Reference

Structural differences between the ready and unready oxidized states of [NiFe] hydrogenases., Volbeda A, Martin L, Cavazza C, Matho M, Faber BW, Roseboom W, Albracht SP, Garcin E, Rousset M, Fontecilla-Camps JC, J Biol Inorg Chem. 2005 May;10(3):239-49. Epub 2005 Apr 1. PMID:15803334

Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas., Volbeda A, Charon MH, Piras C, Hatchikian EC, Frey M, Fontecilla-Camps JC, Nature. 1995 Feb 16;373(6515):580-7. PMID:7854413

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