1yqj

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{{STRUCTURE_1yqj| PDB=1yqj | SCENE= }}
{{STRUCTURE_1yqj| PDB=1yqj | SCENE= }}
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'''Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor'''
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===Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor===
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==Overview==
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Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS-induced TNF-alpha production in mice and exhibited good efficacy in the rat collagen induced arthritis model.
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The line below this paragraph, {{ABSTRACT_PUBMED_15837335}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15837335 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837335}}
==About this Structure==
==About this Structure==
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[[Category: Yu, V.]]
[[Category: Yu, V.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:39:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:02:30 2008''

Revision as of 00:02, 28 July 2008

Template:STRUCTURE 1yqj

Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor

Template:ABSTRACT PUBMED 15837335

About this Structure

1YQJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase., Tamayo N, Liao L, Goldberg M, Powers D, Tudor YY, Yu V, Wong LM, Henkle B, Middleton S, Syed R, Harvey T, Jang G, Hungate R, Dominguez C, Bioorg Med Chem Lett. 2005 May 2;15(9):2409-13. PMID:15837335

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