1yqs

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[[Image:1yqs.gif|left|200px]]
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{{Seed}}
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[[Image:1yqs.png|left|200px]]
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{{STRUCTURE_1yqs| PDB=1yqs | SCENE= }}
{{STRUCTURE_1yqs| PDB=1yqs | SCENE= }}
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'''Inhibition of the R61 DD-Peptidase by N-benzoyl-beta-sultam'''
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===Inhibition of the R61 DD-Peptidase by N-benzoyl-beta-sultam===
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==Overview==
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N-Acyl-beta-sultams are time-dependent, irreversible active site-directed inhibitors of Streptomyces R61 DD-peptidase. The rate of inactivation is first order with respect to beta-sultam concentration, and the second-order rate constants show a dependence on pH similar to that for the hydrolysis of a substrate. Inactivation is due to the formation of a stable 1:1 enzyme-inhibitor complex as a result of the active site serine being sulfonylated by the beta-sultam as shown by ESI-MS analysis and by X-ray crystallography. A striking feature of the sulfonyl enzyme is that the inhibitor is not bound to the oxyanion hole but interacts extensively with the "roof" of the active site where the Arg 285 is located.
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The line below this paragraph, {{ABSTRACT_PUBMED_15909988}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15909988 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15909988}}
==About this Structure==
==About this Structure==
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[[Category: Peptidase]]
[[Category: Peptidase]]
[[Category: Sulfonylation]]
[[Category: Sulfonylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:39:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:59:09 2008''

Revision as of 21:59, 28 July 2008

Image:1yqs.png

Template:STRUCTURE 1yqs

Inhibition of the R61 DD-Peptidase by N-benzoyl-beta-sultam

Template:ABSTRACT PUBMED 15909988

About this Structure

1YQS is a Single protein structure of sequence from Streptomyces sp.. Full crystallographic information is available from OCA.

Reference

Inactivation of bacterial DD-peptidase by beta-sultams., Llinas A, Ahmed N, Cordaro M, Laws AP, Frere JM, Delmarcelle M, Silvaggi NR, Kelly JA, Page MI, Biochemistry. 2005 May 31;44(21):7738-46. PMID:15909988

Page seeded by OCA on Tue Jul 29 00:59:09 2008

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