1ys5

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{{STRUCTURE_1ys5| PDB=1ys5 | SCENE= }}
{{STRUCTURE_1ys5| PDB=1ys5 | SCENE= }}
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'''Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis'''
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===Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis===
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==Overview==
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GNA1870, a 28-kDa surface-exposed lipoprotein of Neisseria meningitidis recently discovered by reverse vaccinology, is one of the most potent antigens of Meningococcus and a promising candidate for a universal vaccine against a devastating disease. Previous studies of epitope mapping and genetic characterization identified residues critical for bactericidal response within the C-terminal domain of the molecule. To elucidate the conformation of protective epitopes, we used NMR spectroscopy to obtain the solution structure of the immunodominant 18-kDa C-terminal portion of GNA1870. The structure consists of an eight-stranded antiparallel beta-barrel overlaid by a short alpha-helix with an unstructured N-terminal end. Residues previously shown to be important for antibody recognition were mapped on loops facing the same ridge of the molecule. The sequence similarity of GNA1870 with members of the bacterial transferrin receptor family allows one to predict the folding of this class of well known bacterial antigens, providing the basis for the rational engineering of high affinity B cell epitopes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16407174 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16407174}}
==About this Structure==
==About this Structure==
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1YS5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YS5 OCA].
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1YS5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YS5 OCA].
==Reference==
==Reference==
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[[Category: Neisseria meningitidi]]
[[Category: Neisseria meningitidi]]
[[Category: Vaccine candidate]]
[[Category: Vaccine candidate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:42:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:35:22 2008''

Revision as of 16:35, 27 July 2008

Image:1ys5.png

Template:STRUCTURE 1ys5

Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis

Template:ABSTRACT PUBMED 16407174

About this Structure

1YS5 is a Single protein structure of sequence from Neisseria meningitidis. Full experimental information is available from OCA.

Reference

Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis., Cantini F, Savino S, Scarselli M, Masignani V, Pizza M, Romagnoli G, Swennen E, Veggi D, Banci L, Rappuoli R, J Biol Chem. 2006 Mar 17;281(11):7220-7. Epub 2005 Dec 31. PMID:16407174

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