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1ysf

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[[Image:1ysf.jpg|left|200px]]
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{{STRUCTURE_1ysf| PDB=1ysf | SCENE= }}
{{STRUCTURE_1ysf| PDB=1ysf | SCENE= }}
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'''The solution structure of the N-domain of the transcription factor abrB'''
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===The solution structure of the N-domain of the transcription factor abrB===
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==Overview==
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AbrB is a key transition-state regulator of Bacillus subtilis. Based on the conservation of a betaalphabeta structural unit, we proposed a beta barrel fold for its DNA binding domain, similar to, but topologically distinct from, double-psi beta barrels. However, the NMR structure revealed a novel fold, the "looped-hinge helix." To understand this discrepancy, we undertook a bioinformatics study of AbrB and its homologs; these form a large superfamily, which includes SpoVT, PrlF, MraZ, addiction module antidotes (PemI, MazE), plasmid maintenance proteins (VagC, VapB), and archaeal PhoU homologs. MazE and MraZ form swapped-hairpin beta barrels. We therefore reexamined the fold of AbrB by NMR spectroscopy and found that it also forms a swapped-hairpin barrel. The conservation of the core betaalphabeta element supports a common evolutionary origin for swapped-hairpin and double-psi barrels, which we group into a higher-order class, the cradle-loop barrels, based on the peculiar shape of their ligand binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 15939023 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15939023}}
==About this Structure==
==About this Structure==
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1YSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSF OCA].
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1YSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSF OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Swapped-hairpin barrel]]
[[Category: Swapped-hairpin barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:43:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:05:19 2008''

Revision as of 13:05, 28 July 2008

Image:1ysf.png

Template:STRUCTURE 1ysf

The solution structure of the N-domain of the transcription factor abrB

Template:ABSTRACT PUBMED 15939023

About this Structure

1YSF is a Single protein structure of sequence from Bacillus subtilis. Full experimental information is available from OCA.

Reference

AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels., Coles M, Djuranovic S, Soding J, Frickey T, Koretke K, Truffault V, Martin J, Lupas AN, Structure. 2005 Jun;13(6):919-28. PMID:15939023

Page seeded by OCA on Mon Jul 28 16:05:19 2008

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