1yt3

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{{STRUCTURE_1yt3| PDB=1yt3 | SCENE= }}
{{STRUCTURE_1yt3| PDB=1yt3 | SCENE= }}
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'''Crystal Structure of Escherichia coli RNase D, an exoribonuclease involved in structured RNA processing'''
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===Crystal Structure of Escherichia coli RNase D, an exoribonuclease involved in structured RNA processing===
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==Overview==
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RNase D (RND) is one of seven exoribonucleases identified in Escherichia coli. RNase D has homologs in many eubacteria and eukaryotes, and has been shown to contribute to the 3' maturation of several stable RNAs. Here, we report the 1.6 A resolution crystal structure of E. coli RNase D. The conserved DEDD residues of RNase D fold into an arrangement very similar to the Klenow fragment exonuclease domain. Besides the catalytic domain, RNase D also contains two structurally similar alpha-helical domains with no discernible sequence homology between them. These closely resemble the HRDC domain previously seen in RecQ-family helicases and several other proteins acting on nucleic acids. More interestingly, the DEDD catalytic domain and the two helical domains come together to form a ring-shaped structure. The ring-shaped architecture of E. coli RNase D and the HRDC domains likely play a major role in determining the substrate specificity of this exoribonuclease.
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{{ABSTRACT_PUBMED_16004870}}
==About this Structure==
==About this Structure==
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[[Category: Rnase]]
[[Category: Rnase]]
[[Category: Trna processing]]
[[Category: Trna processing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:45:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:32:41 2008''

Revision as of 13:32, 28 July 2008

Image:1yt3.png

Template:STRUCTURE 1yt3

Crystal Structure of Escherichia coli RNase D, an exoribonuclease involved in structured RNA processing

Template:ABSTRACT PUBMED 16004870

About this Structure

1YT3 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli RNase D, an exoribonuclease involved in structured RNA processing., Zuo Y, Wang Y, Malhotra A, Structure. 2005 Jul;13(7):973-84. PMID:16004870

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