1yu2

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[[Image:1yu2.gif|left|200px]]
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{{Seed}}
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[[Image:1yu2.png|left|200px]]
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{{STRUCTURE_1yu2| PDB=1yu2 | SCENE= }}
{{STRUCTURE_1yu2| PDB=1yu2 | SCENE= }}
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'''Major Tropism Determinant M1 Variant'''
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===Major Tropism Determinant M1 Variant===
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==Overview==
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Only few instances are known of protein folds that tolerate massive sequence variation for the sake of binding diversity. The most extensively characterized is the immunoglobulin fold. We now add to this the C-type lectin (CLec) fold, as found in the major tropism determinant (Mtd), a retroelement-encoded receptor-binding protein of Bordetella bacteriophage. Variation in Mtd, with its approximately 10(13) possible sequences, enables phage adaptation to Bordetella spp. Mtd is an intertwined, pyramid-shaped trimer, with variable residues organized by its CLec fold into discrete receptor-binding sites. The CLec fold provides a highly static scaffold for combinatorial display of variable residues, probably reflecting a different evolutionary solution for balancing diversity against stability from that in the immunoglobulin fold. Mtd variants are biased toward the receptor pertactin, and there is evidence that the CLec fold is used broadly for sequence variation by related retroelements.
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The line below this paragraph, {{ABSTRACT_PUBMED_16170324}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16170324 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16170324}}
==About this Structure==
==About this Structure==
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[[Category: Diversity-generating retroelement]]
[[Category: Diversity-generating retroelement]]
[[Category: Variability]]
[[Category: Variability]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:47:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:56:53 2008''

Revision as of 09:56, 27 July 2008

Image:1yu2.png

Template:STRUCTURE 1yu2

Major Tropism Determinant M1 Variant

Template:ABSTRACT PUBMED 16170324

About this Structure

1YU2 is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.

Reference

The C-type lectin fold as an evolutionary solution for massive sequence variation., McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P, Nat Struct Mol Biol. 2005 Oct;12(10):886-92. Epub 2005 Sep 18. PMID:16170324

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