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1yu9

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{{STRUCTURE_1yu9| PDB=1yu9 | SCENE= }}
{{STRUCTURE_1yu9| PDB=1yu9 | SCENE= }}
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'''GppNHp-Bound Rab4A'''
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===GppNHp-Bound Rab4A===
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==Overview==
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Rab GTPases regulate all stages of membrane trafficking, including vesicle budding, cargo sorting, transport, tethering and fusion. In the inactive (GDP-bound) conformation, accessory factors facilitate the targeting of Rab GTPases to intracellular compartments. After nucleotide exchange to the active (GTP-bound) conformation, Rab GTPases interact with functionally diverse effectors including lipid kinases, motor proteins and tethering complexes. How effectors distinguish between homologous Rab GTPases represents an unresolved problem with respect to the specificity of vesicular trafficking. Using a structural proteomic approach, we have determined the specificity and structural basis underlying the interaction of the multivalent effector rabenosyn-5 with the Rab family. The results demonstrate that even the structurally similar effector domains in rabenosyn-5 can achieve highly selective recognition of distinct subsets of Rab GTPases exclusively through interactions with the switch and interswitch regions. The observed specificity is determined at a family-wide level by structural diversity in the active conformation, which governs the spatial disposition of critical conserved recognition determinants, and by a small number of both positive and negative sequence determinants that allow further discrimination between Rab GTPases with similar switch conformations.
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{{ABSTRACT_PUBMED_16034420}}
==About this Structure==
==About this Structure==
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[[Category: Rab4]]
[[Category: Rab4]]
[[Category: Vesicular trafficking]]
[[Category: Vesicular trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:47:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:37:04 2008''

Revision as of 10:37, 27 July 2008

Image:1yu9.png

Template:STRUCTURE 1yu9

GppNHp-Bound Rab4A

Template:ABSTRACT PUBMED 16034420

About this Structure

1YU9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5., Eathiraj S, Pan X, Ritacco C, Lambright DG, Nature. 2005 Jul 21;436(7049):415-9. PMID:16034420

Page seeded by OCA on Sun Jul 27 13:37:04 2008

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