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1yuh

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[[Image:1yuh.jpg|left|200px]]
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{{Seed}}
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[[Image:1yuh.png|left|200px]]
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{{STRUCTURE_1yuh| PDB=1yuh | SCENE= }}
{{STRUCTURE_1yuh| PDB=1yuh | SCENE= }}
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'''FAB FRAGMENT'''
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===FAB FRAGMENT===
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==Overview==
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Affinity maturation of the immune response to nitrophenol-containing antigens has been extensively investigated. Significant strides made during the past several years with the advent of PCR technology have provided a wealth of biochemical knowledge. Structural investigations of the phenomena have however been limited. We have determined the three-dimensional structure of the Fab fragment of 88C6/12, an anti-4-hydroxy-3-nitrophenyl acetic acid antibody complexed with the immunizing hapten and with a heteroclitic iodinated hapten. The crystallographic structure of the complexes reveals that the binding is stabilized by a number of hydrogen bonds and extensive van der Waals interactions between the hapten and the antibody. In addition, the Fab binding pocket contains a region of positive electrostatic potential well suited for interaction with the predominant resonance form of the nitrophenyl ring system. The observed heteroclicity towards the iodinated hapten is not a direct result of iodine-protein interactions, but results from the enhanced stability in the iodinated ring of the resonance form that binds the antibody. In addition this investigation provides a rationale for the strong preference for the substitution in the heavy chain from the germ-line gene encoded Trp 33 to Leu 33 in the mature anti-nitrophenol response.
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The line below this paragraph, {{ABSTRACT_PUBMED_8544863}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8544863 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8544863}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Lambda light chain]]
[[Category: Lambda light chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:48:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:16:11 2008''

Revision as of 02:16, 28 July 2008

Image:1yuh.png

Template:STRUCTURE 1yuh

FAB FRAGMENT

Template:ABSTRACT PUBMED 8544863

About this Structure

1YUH is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Structural analysis of affinity maturation: the three-dimensional structures of complexes of an anti-nitrophenol antibody., Yuhasz SC, Parry C, Strand M, Amzel LM, Mol Immunol. 1995 Oct;32(14-15):1143-55. PMID:8544863

Page seeded by OCA on Mon Jul 28 05:16:11 2008

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