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1ywf

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{{STRUCTURE_1ywf| PDB=1ywf | SCENE= }}
{{STRUCTURE_1ywf| PDB=1ywf | SCENE= }}
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'''Crystal Structure of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase PtpB'''
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===Crystal Structure of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase PtpB===
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==Overview==
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Intracellular pathogenic bacteria manipulate host signal transduction pathways to facilitate infection. Mycobacterium tuberculosis protein tyrosine phosphatases (PTPs) PtpA and PtpB are thought to be secreted into host cells and interfere with unidentified signals. To illuminate the mechanisms of regulation and substrate recognition, we determined the 1.7 A resolution crystal structure of PtpB in complex with the product phosphate. The protein adopts a simplified PTP fold, which combines features of the conventional PTPs and dual-specificity phosphatases. PtpB shows two unusual elaborations--a disordered, acidic loop and a flexible, two-helix lid that covers the active site--that are specific to mycobacterial orthologs. Biochemical studies suggest that substrate mimicry in the lid may protect the phosphatase from oxidative inactivation. The insertion and deletion of large structural elements in PtpB suggest that, outside the active site module, the PTP family is under unusual selective pressure that promotes changes in overall structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 16271885 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16271885}}
==About this Structure==
==About this Structure==
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[[Category: Tb structural genomics consortium]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:52:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:10:10 2008''

Revision as of 01:10, 29 July 2008

Image:1ywf.png

Template:STRUCTURE 1ywf

Crystal Structure of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase PtpB

Template:ABSTRACT PUBMED 16271885

About this Structure

1YWF is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site., Grundner C, Ng HL, Alber T, Structure. 2005 Nov;13(11):1625-34. PMID:16271885

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