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1yxw

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{{STRUCTURE_1yxw| PDB=1yxw | SCENE= }}
{{STRUCTURE_1yxw| PDB=1yxw | SCENE= }}
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'''A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin'''
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===A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin===
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==Overview==
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Clostridial neurotoxins are comprised of botulinum (BoNT) and tetanus (TeNT), which share significant structural and functional similarity. Crystal structures of the binding domain of TeNT complexed with disialyllactose (DiSia) and a tri-peptide Tyr-Glu-Trp (YEW) have been determined to 2.3 and 2.2 A, respectively. Both DiSia and YEW bind in a shallow cleft region on the surface of the molecule in the beta-trefoil domain, interacting with a set of common residues, Asp1147, Asp1214, Asn1216, and Arg1226. DiSia and YEW binding at the same site in tetanus toxin provides a putative site that could be occupied either by a ganglioside moiety or a peptide. Soaking experiments with a mixture of YEW and DiSia show that YEW competes with DiSia, suggesting that YEW can be used to block ganglioside binding. A comparison with the TeNT binding domain in complex with small molecules, BoNT/A and /B, provides insight into the different modes of ganglioside binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 16104015 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16104015}}
==About this Structure==
==About this Structure==
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[[Category: Tetanus toxin]]
[[Category: Tetanus toxin]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:56:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:20:58 2008''

Revision as of 04:21, 29 July 2008

Image:1yxw.png

Template:STRUCTURE 1yxw

A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin

Template:ABSTRACT PUBMED 16104015

About this Structure

1YXW is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

Reference

Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin., Jayaraman S, Eswaramoorthy S, Kumaran D, Swaminathan S, Proteins. 2005 Nov 1;61(2):288-95. PMID:16104015

Page seeded by OCA on Tue Jul 29 07:20:58 2008

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