1yz9

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{{STRUCTURE_1yz9| PDB=1yz9 | SCENE= }}
{{STRUCTURE_1yz9| PDB=1yz9 | SCENE= }}
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'''Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution'''
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===Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution===
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==Overview==
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Bacterial ribonuclease III (RNase III) can affect RNA structure and gene expression in either of two ways: as a processing enzyme that cleaves double-stranded (ds) RNA, or as a binding protein that binds but does not cleave dsRNA. We previously proposed a model of the catalytic complex of RNase III with dsRNA based on three crystal structures, including the endonuclease domain of RNase III with and without bound metal ions and a dsRNA binding protein complexed with dsRNA. We also reported a noncatalytic assembly observed in the crystal structure of an RNase III mutant, which binds but does not cleave dsRNA, complexed with dsRNA. We hypothesize that the RNase III*dsRNA complex can exist in two functional forms, a catalytic complex and a noncatalytic assembly, and that in between the two forms there may be intermediate states. Here, we present four crystal structures of RNase III complexed with dsRNA, representing possible intermediates.
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The line below this paragraph, {{ABSTRACT_PUBMED_16216575}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16216575 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16216575}}
==About this Structure==
==About this Structure==
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[[Category: Ribonuclease iii]]
[[Category: Ribonuclease iii]]
[[Category: Rna interference]]
[[Category: Rna interference]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:59:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:34:21 2008''

Revision as of 10:34, 27 July 2008

Image:1yz9.png

Template:STRUCTURE 1yz9

Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution

Template:ABSTRACT PUBMED 16216575

About this Structure

1YZ9 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Intermediate states of ribonuclease III in complex with double-stranded RNA., Gan J, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X, Structure. 2005 Oct;13(10):1435-42. PMID:16216575

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