1z21

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[[Image:1z21.gif|left|200px]]
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{{Seed}}
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[[Image:1z21.png|left|200px]]
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{{STRUCTURE_1z21| PDB=1z21 | SCENE= }}
{{STRUCTURE_1z21| PDB=1z21 | SCENE= }}
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'''Crystal structure of the core domain of Yersinia pestis virulence factor YopR'''
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===Crystal structure of the core domain of Yersinia pestis virulence factor YopR===
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==Overview==
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Yersinia pestis, the causative agent of the plague, employs a type III secretion system (T3SS) to secrete and translocate virulence factors into to the cytoplasm of mammalian host cells. One of the secreted virulence factors is YopR. Little is known about the function of YopR other than that it is secreted into the extracellular milieu during the early stages of infection and that it contributes to virulence. Hoping to gain some insight into the function of YopR, we determined the crystal structure of its protease-resistant core domain, which consists of residues 38-149 out of 165 amino acids. The core domain is composed of five alpha-helices that display unexpected structural similarity with one domain of YopN, a central regulator of type III secretion in Y. pestis. This finding raises the possibility that YopR may play a role in the regulation of type III secretion.
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(as it appears on PubMed at http://www.pubmed.gov), where 15930010 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15930010}}
==About this Structure==
==About this Structure==
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[[Category: Yop]]
[[Category: Yop]]
[[Category: Yopr]]
[[Category: Yopr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:05:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:02:01 2008''

Revision as of 21:02, 28 July 2008

Image:1z21.png

Template:STRUCTURE 1z21

Crystal structure of the core domain of Yersinia pestis virulence factor YopR

Template:ABSTRACT PUBMED 15930010

About this Structure

1Z21 is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR., Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS, Protein Sci. 2005 Jun;14(6):1679-83. PMID:15930010

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