1z24

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[[Image:1z24.gif|left|200px]]
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{{STRUCTURE_1z24| PDB=1z24 | SCENE= }}
{{STRUCTURE_1z24| PDB=1z24 | SCENE= }}
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'''The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.'''
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===The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.===
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==Overview==
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Insecticyanin, a blue biliprotein isolated from the tobacco hornworm Manduca sexta L., is involved in insect camouflage. Its three-dimensional structure has now been solved to 2.6 A resolution using the techniques of multiple isomorphous replacement, non-crystallographic symmetry averaging about a local 2-fold rotation axis and solvent flattening. All 189 amino acids have been fitted to the electron density map. The map clearly shows that insecticyanin is a tetramer with one of its molecular 2-fold axes coincident to a crystallographic dyad. The individual subunits have overall dimensions of 44 A X 37 A X 40 A and consist primarily of an eight-stranded anti-parallel beta-barrel flanked on one side by a 4.5-turn alpha-helix. Interestingly the overall three-dimensional fold of the insecticyanin subunit shows remarkable similarity to the structural motifs of bovine beta-lactoglobulin and the human serum retinol-binding protein. The electron density attributable to the chromophore is unambiguous and shows that it is indeed the gamma-isomer of biliverdin. The biliverdin lies towards the open end of the beta-barrel with its two propionate side chains pointing towards the solvent and it adopts a rather folded conformation, much like a heme.
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The line below this paragraph, {{ABSTRACT_PUBMED_3608987}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 3608987 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3608987}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution., Holden HM, Rypniewski WR, Law JH, Rayment I, EMBO J. 1987 Jun;6(6):1565-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3608987 3608987]
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution., Holden HM, Rypniewski WR, Law JH, Rayment I, EMBO J. 1987 Jun;6(6):1565-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3608987 3608987]
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Crystallization of insecticyanin from the hemolymph of the tobacco hornworm Manduca sexta L. in a form suitable for a high resolution structure determination., Holden HM, Law JH, Rayment I, J Biol Chem. 1986 Mar 25;261(9):4217-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3949808 3949808]
[[Category: Manduca sexta]]
[[Category: Manduca sexta]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Chromophore binding.]]
[[Category: Chromophore binding.]]
[[Category: Ins-a]]
[[Category: Ins-a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:05:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:33:50 2008''

Revision as of 17:33, 27 July 2008

Image:1z24.png

Template:STRUCTURE 1z24

The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.

Template:ABSTRACT PUBMED 3608987

About this Structure

1Z24 is a Single protein structure of sequence from Manduca sexta. Full crystallographic information is available from OCA.

Reference

The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution., Holden HM, Rypniewski WR, Law JH, Rayment I, EMBO J. 1987 Jun;6(6):1565-70. PMID:3608987

Crystallization of insecticyanin from the hemolymph of the tobacco hornworm Manduca sexta L. in a form suitable for a high resolution structure determination., Holden HM, Law JH, Rayment I, J Biol Chem. 1986 Mar 25;261(9):4217-8. PMID:3949808

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