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1z2b

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[[Image:1z2b.gif|left|200px]]
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{{STRUCTURE_1z2b| PDB=1z2b | SCENE= }}
{{STRUCTURE_1z2b| PDB=1z2b | SCENE= }}
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'''Tubulin-colchicine-vinblastine: stathmin-like domain complex'''
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===Tubulin-colchicine-vinblastine: stathmin-like domain complex===
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==Overview==
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Vinblastine is one of several tubulin-targeting Vinca alkaloids that have been responsible for many chemotherapeutic successes since their introduction in the clinic as antitumour drugs. In contrast with the two other classes of small tubulin-binding molecules (Taxol and colchicine), the binding site of vinblastine is largely unknown and the molecular mechanism of this drug has remained elusive. Here we report the X-ray structure of vinblastine bound to tubulin in a complex with the RB3 protein stathmin-like domain (RB3-SLD). Vinblastine introduces a wedge at the interface of two tubulin molecules and thus interferes with tubulin assembly. Together with electron microscopical and biochemical data, the structure explains vinblastine-induced tubulin self-association into spiral aggregates at the expense of microtubule growth. It also shows that vinblastine and the amino-terminal part of RB3-SLD binding sites share a hydrophobic groove on the alpha-tubulin surface that is located at an intermolecular contact in microtubules. This is an attractive target for drugs designed to perturb microtubule dynamics by interfacial interference, for which tubulin seems ideally suited because of its propensity to self-associate.
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The line below this paragraph, {{ABSTRACT_PUBMED_15917812}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15917812 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15917812}}
==About this Structure==
==About this Structure==
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[[Category: Tubulin]]
[[Category: Tubulin]]
[[Category: Vinblastine]]
[[Category: Vinblastine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:06:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:03:17 2008''

Revision as of 07:03, 28 July 2008

Image:1z2b.png

Template:STRUCTURE 1z2b

Tubulin-colchicine-vinblastine: stathmin-like domain complex

Template:ABSTRACT PUBMED 15917812

About this Structure

1Z2B is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis for the regulation of tubulin by vinblastine., Gigant B, Wang C, Ravelli RB, Roussi F, Steinmetz MO, Curmi PA, Sobel A, Knossow M, Nature. 2005 May 26;435(7041):519-22. PMID:15917812

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