1z2p

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{{STRUCTURE_1z2p| PDB=1z2p | SCENE= }}
{{STRUCTURE_1z2p| PDB=1z2p | SCENE= }}
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'''Inositol 1,3,4-trisphosphate 5/6-Kinase in complex with Mg2+/AMP-PCP/Ins(1,3,4)P3'''
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===Inositol 1,3,4-trisphosphate 5/6-Kinase in complex with Mg2+/AMP-PCP/Ins(1,3,4)P3===
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==Overview==
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Inositol hexakisphosphate and other inositol high polyphosphates have diverse and critical roles in eukaryotic regulatory pathways. Inositol 1,3,4-trisphosphate 5/6-kinase catalyzes the rate-limiting step in inositol high polyphosphate synthesis in animals. This multifunctional enzyme also has inositol 3,4,5,6-tetrakisphosphate 1-kinase and other activities. The structure of an archetypal family member, from Entamoeba histolytica, has been determined to 1.2 A resolution in binary and ternary complexes with nucleotide, substrate, and product. The structure reveals an ATP-grasp fold. The inositol ring faces ATP edge-on such that the 5- and 6-hydroxyl groups are nearly equidistant from the ATP gamma-phosphate in catalytically productive phosphoacceptor positions and explains the unusual dual site specificity of this kinase. Inositol tris- and tetrakisphosphates interact via three phosphate binding subsites and one solvent-exposed site that could in principle be occupied by 18 different substrates, explaining the mechanisms for the multiple specificities and catalytic activities of this enzyme.
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{{ABSTRACT_PUBMED_15837423}}
==About this Structure==
==About this Structure==
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[[Category: Atp-grasp]]
[[Category: Atp-grasp]]
[[Category: Inositol phosphate kinase]]
[[Category: Inositol phosphate kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:06:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:27:02 2008''

Revision as of 10:27, 28 July 2008

Image:1z2p.png

Template:STRUCTURE 1z2p

Inositol 1,3,4-trisphosphate 5/6-Kinase in complex with Mg2+/AMP-PCP/Ins(1,3,4)P3

Template:ABSTRACT PUBMED 15837423

About this Structure

1Z2P is a Single protein structure of sequence from Eukaryota. Full crystallographic information is available from OCA.

Reference

Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase., Miller GJ, Wilson MP, Majerus PW, Hurley JH, Mol Cell. 2005 Apr 15;18(2):201-12. PMID:15837423

Page seeded by OCA on Mon Jul 28 13:27:02 2008

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