1z3g

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[[Image:1z3g.gif|left|200px]]
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{{Seed}}
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[[Image:1z3g.png|left|200px]]
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{{STRUCTURE_1z3g| PDB=1z3g | SCENE= }}
{{STRUCTURE_1z3g| PDB=1z3g | SCENE= }}
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'''Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8'''
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===Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8===
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==Overview==
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P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
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The line below this paragraph, {{ABSTRACT_PUBMED_16327807}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16327807 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16327807}}
==About this Structure==
==About this Structure==
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[[Category: 2a8 fab]]
[[Category: 2a8 fab]]
[[Category: Pvs25]]
[[Category: Pvs25]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:08:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:32:11 2008''

Revision as of 04:32, 28 July 2008

Image:1z3g.png

Template:STRUCTURE 1z3g

Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8

Template:ABSTRACT PUBMED 16327807

About this Structure

1Z3G is a Single protein structure of sequence from Mus musculus and Plasmodium vivax. Full crystallographic information is available from OCA.

Reference

The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807

Page seeded by OCA on Mon Jul 28 07:32:11 2008

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