1z3h

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[[Image:1z3h.gif|left|200px]]
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{{Seed}}
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[[Image:1z3h.png|left|200px]]
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{{STRUCTURE_1z3h| PDB=1z3h | SCENE= }}
{{STRUCTURE_1z3h| PDB=1z3h | SCENE= }}
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'''The exportin Cse1 in its cargo-free, cytoplasmic state'''
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===The exportin Cse1 in its cargo-free, cytoplasmic state===
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==Overview==
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Cse1 mediates nuclear export of importin alpha, the nuclear localization signal (NLS) import adaptor. We report the 3.1 A resolution structure of cargo-free Cse1, representing this HEAT repeat protein in its cytosolic state. Cse1 is compact, consisting of N- and C-terminal arches that interact to form a ring. Comparison with the structure of cargo-bound Cse1 shows a major conformational change leading to opening of the structure upon cargo binding. The largest structural changes occur within a hinge region centered at HEAT repeat 8. This repeat contains a conserved insertion that connects the RanGTP and importin alpha contact sites and that is essential for binding. In the cargo-free state, the RanGTP binding sites are occluded and the importin alpha sites are distorted. Mutations that destabilize the N- to C-terminal interaction uncouple importin alpha and Ran binding, suggesting that the closed conformation prevents association with importin alpha.
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The line below this paragraph, {{ABSTRACT_PUBMED_15866177}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15866177 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15866177}}
==About this Structure==
==About this Structure==
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[[Category: Heat repeat]]
[[Category: Heat repeat]]
[[Category: Nuclear transport]]
[[Category: Nuclear transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:08:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:03:11 2008''

Revision as of 08:03, 28 July 2008

Image:1z3h.png

Template:STRUCTURE 1z3h

The exportin Cse1 in its cargo-free, cytoplasmic state

Template:ABSTRACT PUBMED 15866177

About this Structure

1Z3H is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding., Cook A, Fernandez E, Lindner D, Ebert J, Schlenstedt G, Conti E, Mol Cell. 2005 Apr 29;18(3):355-67. PMID:15866177

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