1z3u

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{{STRUCTURE_1z3u| PDB=1z3u | SCENE= }}
{{STRUCTURE_1z3u| PDB=1z3u | SCENE= }}
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'''Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition'''
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===Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition===
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==Overview==
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The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although highly homologous, can function as agonists or antagonists in a context-dependent manner. In an effort to understand this molecular dichotomy, we have crystallized and determined the 2.4 A crystal structure of the Angiopoietin-2 (Ang2) receptor binding region. The structure reveals a fibrinogen fold with a unique C-terminal P domain. Conservation analysis and structure-based mutagenesis identify a groove on the Ang2 molecular surface that mediates receptor recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 15893672 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15893672}}
==About this Structure==
==About this Structure==
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[[Category: Extracellular ligand]]
[[Category: Extracellular ligand]]
[[Category: Tie2 binding]]
[[Category: Tie2 binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:09:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:52:49 2008''

Revision as of 02:52, 28 July 2008

Image:1z3u.png

Template:STRUCTURE 1z3u

Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition

Template:ABSTRACT PUBMED 15893672

About this Structure

1Z3U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition., Barton WA, Tzvetkova D, Nikolov DB, Structure. 2005 May;13(5):825-32. PMID:15893672

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