1z3y

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[[Image:1z3y.gif|left|200px]]
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{{Seed}}
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[[Image:1z3y.png|left|200px]]
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{{STRUCTURE_1z3y| PDB=1z3y | SCENE= }}
{{STRUCTURE_1z3y| PDB=1z3y | SCENE= }}
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'''Structure of Gun4-1 from Thermosynechococcus elongatus'''
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===Structure of Gun4-1 from Thermosynechococcus elongatus===
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==Overview==
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Gun4 has been implicated in a developmental signaling pathway between the chloroplast and the nucleus involving magnesium protoporphyrin IX (MgP(IX)), the first dedicated intermediate in the chlorophyll biosynthetic pathway. Here we present the crystal structure of Thermosynechococcus elongatus Gun4 at 1.5 A, describe the binding affinities of Gun4 for substrate and product porphyrin molecules, and identify a likely (Mg)P(IX) binding site on the protein. Kinetic analyses show that Gun4 dramatically increases the efficiency of transformation of porphyrin substrate to metalloporphyrin product and that it also reduces the threshold Mg2+ concentration required for activity at low porphyrin concentration. Gun4 therefore controls magnesium chelatase at physiologically significant Mg2+ concentrations and likely acts as a molecular switch in vivo so that in its absence magnesium chelatase is inactive. This mechanism could allow Gun4 to mediate magnesium protoporphyrin levels both for chlorophyll biosynthesis and for signaling to the nucleus.
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(as it appears on PubMed at http://www.pubmed.gov), where 15909975 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15909975}}
==About this Structure==
==About this Structure==
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[[Category: Schubert, H L.]]
[[Category: Schubert, H L.]]
[[Category: Transferase activator]]
[[Category: Transferase activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:09:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:05:50 2008''

Revision as of 13:05, 28 July 2008

Image:1z3y.png

Template:STRUCTURE 1z3y

Structure of Gun4-1 from Thermosynechococcus elongatus

Template:ABSTRACT PUBMED 15909975

About this Structure

1Z3Y is a Single protein structure of sequence from Thermosynechococcus elongatus. Full crystallographic information is available from OCA.

Reference

Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis., Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP, Hunter CN, Biochemistry. 2005 May 31;44(21):7603-12. PMID:15909975

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