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1z40

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{{STRUCTURE_1z40| PDB=1z40 | SCENE= }}
{{STRUCTURE_1z40| PDB=1z40 | SCENE= }}
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'''AMA1 from Plasmodium falciparum'''
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===AMA1 from Plasmodium falciparum===
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==Overview==
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Apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate that possesses polymorphisms that may pose a problem for a vaccine based on this antigen. Knowledge of the distribution of the polymorphic sites on the surface of AMA1 is necessary to obtain a detailed understanding of their significance for vaccine development. For this reason we have sought to determine the three-dimensional structure of AMA1 using x-ray crystallography. The central two-thirds of AMA1 is relatively conserved among Plasmodium species as well as more distantly related apicomplexan parasites, and contains two clusters of disulfide-bonded cysteines termed domains I and II. The crystal structure of this fragment of AMA1 reported here reveals that domains I+II consists of two intimately associated PAN domains. PAN domain I contains many long loops that extend from the domain core and form a scaffold for numerous polymorphic residues. This extreme adaptation of a PAN domain reveals how malaria parasites have introduced significant flexibility and variation into AMA1 to evade protective human antibody responses. The polymorphisms on the AMA1 surface are exclusively located on one side of the molecule, presumably because this region of AMA1 is most accessible to antibodies reacting with the parasite surface. Moreover, the most highly polymorphic residues surround a conserved hydrophobic trough that is ringed by domain I and domain II loops. Precedents set by viral receptor proteins would suggest that this is likely to be the AMA1 receptor binding pocket.
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(as it appears on PubMed at http://www.pubmed.gov), where 16129835 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16129835}}
==About this Structure==
==About this Structure==
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[[Category: Malaria vaccine candidate]]
[[Category: Malaria vaccine candidate]]
[[Category: Pan or apple domain]]
[[Category: Pan or apple domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:19:36 2008''

Revision as of 18:19, 27 July 2008

Image:1z40.png

Template:STRUCTURE 1z40

AMA1 from Plasmodium falciparum

Template:ABSTRACT PUBMED 16129835

About this Structure

1Z40 is a Single protein structure of sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

Reference

Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket., Bai T, Becker M, Gupta A, Strike P, Murphy VJ, Anders RF, Batchelor AH, Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12736-41. Epub 2005 Aug 29. PMID:16129835

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