1z4h

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[[Image:1z4h.gif|left|200px]]
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{{STRUCTURE_1z4h| PDB=1z4h | SCENE= }}
{{STRUCTURE_1z4h| PDB=1z4h | SCENE= }}
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'''The response regulator TorI belongs to a new family of atypical excisionase'''
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===The response regulator TorI belongs to a new family of atypical excisionase===
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==Overview==
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TorI (Tor inhibition protein) has been identified in Escherichia coli as a protein inhibitor acting through protein-protein interaction with the TorR response regulator. This interaction, which does not interfere with TorR DNA binding activity, probably prevents the recruitment of RNA polymerase to the torC promoter. In this study we have solved the solution structure of TorI, which adopts a prokaryotic winged-helix arrangement. Despite no primary sequence similarity, the three-dimensional structure of TorI is highly homologous to the (lambda)Xis, Mu bacteriophage repressor (MuR-DBD), and transposase (MuA-DBD) structures. We propose that the TorI protein is the structural missing link between the (lambda)Xis and MuR proteins. Moreover, in vivo assays demonstrated that TorI plays an essential role in prophage excision. Heteronuclear NMR experiments and site-directed mutagenesis studies have pinpointed out key residues involved in the DNA binding activity of TorI. Our findings suggest that TorI-related proteins identified in various pathogenic bacterial genomes define a new family of atypical excisionases.
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{{ABSTRACT_PUBMED_16079126}}
==About this Structure==
==About this Structure==
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1Z4H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4H OCA].
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1Z4H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4H OCA].
==Reference==
==Reference==
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[[Category: Reverse turn]]
[[Category: Reverse turn]]
[[Category: Winged helix]]
[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:10:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:59:05 2008''

Revision as of 11:59, 28 July 2008

Image:1z4h.png

Template:STRUCTURE 1z4h

The response regulator TorI belongs to a new family of atypical excisionase

Template:ABSTRACT PUBMED 16079126

About this Structure

1Z4H is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor., Elantak L, Ansaldi M, Guerlesquin F, Mejean V, Morelli X, J Biol Chem. 2005 Nov 4;280(44):36802-8. Epub 2005 Aug 2. PMID:16079126

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