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1z5l

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[[Image:1z5l.gif|left|200px]]
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{{STRUCTURE_1z5l| PDB=1z5l | SCENE= }}
{{STRUCTURE_1z5l| PDB=1z5l | SCENE= }}
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'''Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D'''
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===Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D===
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==Overview==
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Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specificity for self glycosphingolipids and microbial cell wall alpha-glycuronosylceramide antigens presented by CD1d molecules. Here we report the crystal structure of CD1d in complex with a short-chain synthetic variant of alpha-galactosylceramide at a resolution of 2.2 A. This structure elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the alpha-linkage as a unique pathogen-specific pattern-recognition motif. Comparison of the binding of altered lipid ligands to CD1d and T cell receptors suggested that the differential T helper type 1-like and T helper type 2-like properties of natural killer T cells may originate largely from differences in their 'loading' in different cell types and hence in their tissue distribution in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 16007091 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16007091}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:29:38 2008''

Revision as of 22:29, 27 July 2008

Image:1z5l.png

Template:STRUCTURE 1z5l

Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D

Template:ABSTRACT PUBMED 16007091

About this Structure

1Z5L is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor., Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L, Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091

Page seeded by OCA on Mon Jul 28 01:29:38 2008

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