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1z66

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[[Image:1z66.gif|left|200px]]
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{{STRUCTURE_1z66| PDB=1z66 | SCENE= }}
{{STRUCTURE_1z66| PDB=1z66 | SCENE= }}
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'''NMR solution structure of domain III of E-protein of tick-borne Langat flavivirus (no RDC restraints)'''
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===NMR solution structure of domain III of E-protein of tick-borne Langat flavivirus (no RDC restraints)===
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==Overview==
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Flaviviruses cause many human diseases, including dengue fever, yellow fever, West Nile viral encephalitis, and hemorrhagic fevers, and are transmitted to their vertebrate hosts by infected mosquitoes and ticks. Domain III of the envelope protein (E-D3) is considered to be the primary viral determinant involved in the virus-host-cell receptor interaction, and thus represents an excellent target for antiviral drug development. Langat (LGT) virus is a naturally attenuated BSL-2 TBE virus and is a model for the pathogenic BSL-3 and BSL-4 viruses in the serogroup. We have determined the solution structure of LGT-E-D3 using heteronuclear NMR spectroscopy. The backbone dynamics of LGT-E-D3 have been investigated using 15N relaxation measurements. A detailed analysis of the solution structure and dynamics of LGT-E-D3 suggests potential residues that could form a surface for molecular recognition, and thereby represent a target site for antiviral therapeutics design.
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{{ABSTRACT_PUBMED_16731969}}
==About this Structure==
==About this Structure==
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1Z66 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Langat_virus Langat virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z66 OCA].
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1Z66 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Langat_virus Langat virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z66 OCA].
==Reference==
==Reference==
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[[Category: White, M A.]]
[[Category: White, M A.]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:13:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:38:54 2008''

Revision as of 00:38, 28 July 2008

Image:1z66.png

Template:STRUCTURE 1z66

NMR solution structure of domain III of E-protein of tick-borne Langat flavivirus (no RDC restraints)

Template:ABSTRACT PUBMED 16731969

About this Structure

1Z66 is a Single protein structure of sequence from Langat virus. Full experimental information is available from OCA.

Reference

NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition., Mukherjee M, Dutta K, White MA, Cowburn D, Fox RO, Protein Sci. 2006 Jun;15(6):1342-55. PMID:16731969

Page seeded by OCA on Mon Jul 28 03:38:54 2008

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